Featuring MSn Capability
Shimadzu's new LCMS-IT-TOF is a novel hybrid mass spectrometer
for biomarker discovery, metabolite identification and human
health research, and ideal for applications in forensics,
drug development, and environmental chemistry. Coupling atmospheric
pressure ionization with Ion-Trap (IT) and Time-of-Flight
(TOF) technologies, the LCMS-IT-TOF delivers high mass accuracy
and high mass resolution (10,000 at 1000 m/z) independent
of MS mode.
The LCMS-IT-TOF allows more qualitative information
about a sample to be collected in a single run.
This enables researchers and scientists to:
- Elucidate structures of new molecules
- Identify impurities and contaminants
- Analyze metabolites and biomarkers to evaluate biological
The LCMS-IT-TOF has been designed to maximize sensitivity
and selectivity by optimizing the ion transport to the TOF
analyzer and redefining the capability of the quadrupole ion
trap. The ion trap is used to focus ions before ejection into
the TOF as well as supporting MSn analysis with effective
precursor ion selection capabilities (resolution > 1,000
at 1,000 m/z).
The new instrument incorporates a host of new technologies
and enhancements, including:
- Compressed Ion Injection (patented)
- Ballistic Ion Extraction (patent pending)
- Dual-Stage Reflectron (patent pending)
- New ion transfer optics
- Temperature control of the flight tube
The source design, desolvation capillary and reduced collision
ion focusing Q-Array were adapted from Shimadzu's successful
single-quad HPLC mass spectrometer.
Combining new, innovative technologies with one of the fastest
polarity switching speeds available, the LCMS-IT-TOF expands
the power of mass spectrometry scanning to deliver unparalleled
performance for the most demanding analytical needs.