Increase uptime

Maintain optimal performance of your system using MALDI EasyCare to manually clean the ion optics and autotune the instrument.

Key features

• Provides access to self-service routine maintenance allowing you to restore performance
• Reduces engineer call-outs, saving time, increasing uptime
• Safe, easy, removal / re-fit of ion optics
• Automated software tuning of deflector and detectors
• No technical expertise required due to software wizard guidance
• Easy upgrade of MALDI-8020 and MALDI-8030 instruments* using software licence
  *EasyCare-ready versions only
• Ideal for demanding applications such as MALDI imaging and high-throughput analysis of biological samples
• Easy integration into the laboratory with benchtop platform

Upgrade for the MALDI-8000 series

Upgrade to suit your workflow:

• MALDI-8020 and dual-polarity MALDI-8030* can be upgraded with MALDI EasyCare functionality using software licence activation from the upgrade kit
  *EasyCare-ready versions only.
• Upgrading to MALDI EasyCare provides you the control you need over increasing uptime with demanding applications such as MALDI imaging and high-throughput analysis of biological samples

Manual source cleaning

Easily remove, clean and re-fit ion optics to restore performance.

Automated software tuning

• No technical expertise is required – step-by-step guidance provided by the software wizard.
• Redirect your laboratory time to value-added activities to improve your productivity – when tuning slide is inserted the software performs the tuning of deflectors and detector for you 

Software wizard provides ‘read-and-click’ guidance and progress information

• Automated deflector tuning by software
• Automated detector tuning by software

MALDI-8000 series provides class-leading performance

• MALDI-8020 EasyCare and MALDI-8030 EasyCare retain the same performance as the MALDI-8020 and MALDI-8030
• The class leading mass resolution and sensitivity provides great value and outstanding data you need for MALDI imaging workflows

Immunohistochemistry MALDI mass spectrometry imaging (IHC-MALDI MSI) of  human tonsil using 20 probes in a single analysis (MALDI image above produced from overlay of probes for CD44 (m/z 1102), CD11b (m/z 1467) and CD20 (m/z 996); full list of probes analysed in experiment listed below)

Experiment details: 30138 profiles acquired at 200 Hz laser speed over duration of 4 hrs 11 mins in positive ion mode at 30 µm spatial resolution on MALDI-8020. Matrix deposition with Shimadzu automated sublimation device iMLayer using DHB MALDI matrix

20-plex markers: CD11b, CD20 , CD3e, CD4, CD44, CD45RO, CD45RA, CD68 , CD8α, ECAD, GZMB, HER2, Histone H3, Ki67, NCAM1 (CD56), PD1, PDGFR-B, PDPN, PR-A/B, PTEN. Probes provided by AmberGen 

Isocratic System

Gradient System

Benefits of using Edman degradation for amino acid sequencing

(1) Guaranteed N-terminal sequence of proteins
(2) No sample pre-treatment required
(3) Differentiation of isobaric amino acids (leucine and isoleucine)
(4) Identification possible even from unknown proteins not registered in databases

Compliance with FDA 21 CFR Part 11

LabSolutions PPSQ software provides compliance with FDA 21 CFR Part 11 guidelines and enables compliance with the security, user management, and audit trail requirements specified by FDA 21 CFR Part 11.

1. Security

Users are managed on the basis of groups, with each user being recognized by means of a username and password. Unique groups can be created by including persons having different access privileges. Clearly defining each user’s access privileges prevents unauthorized changes to settings, instrument operation, and data access.

2. User Management

LabSolutions’ user administration comprises the setting of rights groups and assignment of rights to users just as in Windows. Access rights required for each user can be set by assigning various levels of access to each user. This helps achieve effective user administration and more efficient laboratory operations.

3. Audit Trail

Logins and logouts to the system, changes in users and groups, and the start and completion of acquisition, together with the username and the time, are all recorded. The recorded operational log can be registered in the database to provide traceability.

4. Software Validation

The integrity of the programs that comprise the system and the raw data acquired by instruments can be checked, ensuring the reliability of the system and data. The results of these alteration checks can be managed as printouts.
(Include Fig)

Simple, Easy-to-Use Data Analysis Functions

Specialized protein sequencer software makes it simple to perform the reprocessing of chromatograms, the overlay of multiple chromatograms, and the automatic estimation of amino acid sequences, which are required for sequence analysis.

• Reprocessing of chromatograms required for data analysis
• Overlay of multiple chromatograms
• Automatic estimation of amino acid sequences

• Chromatogram peak integration, printing, and other processes can be performed on a per-sample basis.

• Displays multiple chromatograms. Analysis cycles can be updated simply by clicking a button.
• Window allows easy identification of sequences.

• Calibrates PTH-amino acid retention times.
• Retention times can be edited simply by selecting a PTH-amino acid and clicking a peak.

• Automatically generates a report containing analytical parameters, estimated sequences, yield rates, and other information.

Automatic Sequence Estimation
Sequences are automatically estimated after analysis of each cycle is complete. Up to four candidate amino acids are displayed together with their certainty levels.

Customized Reports
Reports containing information such as analytical parameters, estimated sequences, and yield rates are automatically created.

Yield Graph Display
Initial and repeated yield rates are calculated and displayed in graph form. Amino acids used for calculations can be freely selected.
 

Structure

Using Edman degradation, it derivatizes the amino acids of a protein in order from the N-termini, cleaves the derivatives, and from the HPLC retention times for these cleaved derivatives, identifies the amino acids.

Isocratic System

Baseline Stability

PPSQ series protein sequencers separate PTH-amino acids isocratically. This improves baseline stability and allows high-sensitivity analysis of PTH-amino acids.

Retention Time Reproducibility

Isocratic sequence analysis provides more stable retention times. Therefore, peaks detected in previous cycles can be cancelled using substation chromatogram processing, making it easier to identify sequences.

Higher Detection

Cycle 10 PTH-Val

PPSQ-51A/53A

PPSQ-31B/33B

Cycle 21 PTH-Ile

PPSQ-51A/53A

PPSQ-31B/33B

Sample: Horse myoglobin 10pmol
Results show the subtraction chromatograms by SPD-M30A (PPSQ-51A/53A) and SPD-20A (PPSQ-31B/33B) connected tandemly after Edman degradation.

Environmentally friendly eco-design

Performing PTH-amino acid analysis in an isocratic mode in which eluents are recycled to allow repeated use of the mobile phase makes it possible to reduce liquid waste and running costs.

Gradient System

High-Sensitivity Analysis

A high-sensitivity flow cell enables high-sensitivity detection of PTH-amino acids, which allows for sequential analysis using trace samples.

Analysis of Standard PTH-Amino Acid Mixture

10pmol

500fmol

Analysis Stability

This system has high analysis stability because it is equipped with a high-performance detector and a solvent delivery pump that provides excellent pumping performance, even in the micro flowrate range, combine to ensure high analysis stability. Because chromatograms with good reproducibility can be obtained, peaks detected in the previous cycle can be canceled by performing differential chromatogram processing. This enables easy identification of PTH-amino acids even from trace samples.

Analysis of Horse Myoglobin (10 pmol)

Just how the human brain functions remains one of the greatest unsolved puzzles. To solve this mystery, brain-function imaging for visualization of brain functions has developed rapidly in recent years. In particular, in vivo optical imaging by functional near-infrared spectroscopy (fNIRS) has attracted attention as a technique that supports next-generation brain science. Utilizing its leading-edge science and technology, Shimadzu has developed the LABNIRS, thereby contributing to the still growing field of brain science.

* For Research Use Only. Not for use in diagnostic procedures.

Expanding Range of Research Applications

High Performance

Next-generation optical brain-function measurements start withmulti-channel and high density

Accepts up to 40 sets––2.5 times more than before (142 channels max.).
Spatial resolution doubled for high-density measurements.

High-speed sampling

Captures rapid cerebral blood flow signals in just 6 ms (previously 25 ms).

Reliability of 3 wavelengths and photomultiplier tube achieve superb sensitivity

Three semiconductor laser wavelengths capture more accurate data.
A photomultiplier tube captures the weakest cerebral signals.

Easy Operation

Graphical User Interface

The intuitive user interface permits complex measurements and analysis conditions settings with simple button clicks.

【Measurement Mode】

【1】 Simple design of fiber placements
【2】 The set fiber placements are reflected on the trend graph and map during measurements.

【Analysis Mode】

*3 Patented in Japan 04379155

Outstanding Scalability

• Comprehensive options provide powerful measurement support
• Increase the number of channels according to the aim of the experime

The CELL PICKER system automates the pickup and removal of cell colonies using a pipetter. Easy-to-operate software simplifies the cell pickup process.

Cell pickup can be made even easier by connecting AUTO CHANGER, new optional equipment designed with automation in mind.

Main Applications:

・Construction of cell strains (genome editing cells, iPS cells)
・Recovery of spheroids

CELL PICKER is a trademark of Shimadzu Corporation or its affiliated companies in Japan and/or other countries.
CKX is a trademark or a registered trademark of Olympus Corporation.

Stress-Free Operations

In Pursuit of Automation

In addition to cell colony pickup, using the optional AUTO CHANGER automates related procedures, including the installation of chips directly from the rack, transfer of the seeding plate, and linkage of the seeded wells with images of the cells collected.

Achieves Picking Results Comparable to Manual Processing

Do you have problems with the difficult and unstable procedures during the picking process? By automating cell collection, seeding, and pipette tip replacement, CELL PICKER stabilizes the operations of picking up and removing cell colonies, processes typically reliant on an operator’s skill level. Using the easy-to-operate software, images of the cells can be automatically obtained before and after collection.

Ensuring Traceability

Standardization of Procedures Using Methods

CELL PICKER operates in accordance with pre-configured methods. With methods, the applicable cell type and type of container to use can be configured, enabling support for a variety of cultivation and testing conditions. Methods can be saved, so procedures utilizing the same conditions time can be implemented at any time.

Operation Window

Setting Items:

・Sample (adherent cells or spheroids)

・Mode (picking or removal)

・Sample vessel

・Seeding vessel

・Automatic image capture ON/OFF

Effortless Procedural Records

Procedures can be checked and recorded without burdening the operator due to functions that automatically take images, link the image name and operating conditions, and check the seeding conditions.

Images of Cellular Colonies Can be Obtained before and after Collection Using the Automatic Imaging Function

Images acquired automatically are saved with the name formatted as “date_time_serial number_well number*_before/after.” In addition, summary files are output in which the operating conditions are linked with the image names.

Summary File Example

*Output only by systems equipped with AUTO CHANGER

Features

• Creation of finer matrix crystal grains via the deposition method
• Improved reproducibility of matrix coatings via automatic coating thickness control
• Simple touch panel operation

The iMLayer AERO incorporates a sample stage that moves at a controlled rate while maintaining the same distance from the spray nozzle, enabling stable matrix spraying.
Over multiple strokes, the sample becomes laminated with fine matrix crystals, enabling high sensitivity and high spatial resolution.

Work Flow

Imaging with High Reproducibility

Humidity Control

Humidity does not impact matrix deposition because the atmosphere within the spray chamber is replaced before pretreatment. Spraying can be performed under more stable conditions than with a hand spray.

Clog-Free Reagent Delivery

If the matrix clogs the nozzle tip, the spray becomes unstable, which can lead to lower reproducibility. The rinsing mechanism allows for clog-free, stable spraying, which enables high reproducibility in MALDI analyses.

Both Sensitivity and Spatial Resolution Achieved

Excellent Spray Performance

The standard protocol provides sensitivity on par with a hand spray along with improved resolution, homogeneity and reproducibility

Two-Step Vapor Deposition

To acquire high spatial resolution (5 to 10 μm) images and increase sensitivity, a two-step vapor deposition method can be implemented in combination with the iMLayer matrix vapor deposition system has been developed.* This unique experiment can only be implemented using Shimadzu sample preparation solutions.

* Patent No.: JP6153139 and JP6183779

Two-Step Vapor Deposition Allows for Very Fine Images with Minimal Blur

Hand Spray

• Matrix：9-AA
• Volume used：200 μL

Two-Step Vapor Deposition1 step：iMLayer（vapor deposition method） 

• Film thickness：1 μm

 2 step：iMLayer AERO（spray method)） 

• Solution delivery volume：120 μL/min
• Stage speed：70 mm/sec
• Laminating layers：4

Applicable to Pretreatment Other than Matrix Coatings

Derivatization Treatment

With its simple configuration and compact size, it is possible to install the MALDImini-1 in places where mass analysis devices could not previously be used. Through ingenious engineering and innovation its footprint has been reduced to the size of a piece of paper.

“Minimum” time

Miniaturization allows rapid, “on-the-spot” analysis and simplifies data acquisition.

“Minimum” sample volume

Complex structural analysis can be performed even with sub-μL sample volumes.

“Minimum” footprint

The MALDI-MS that can be installed anywhere

Until now, devices for MSⁿ have had strenuous installation requirements, but the MALDImini-1’s compact size and power requirements make it easy to install almost anywhere. Easy access to the instrument allows users to quickly acquire data and check their results, creating a more convenient workflow right on the bench.

“Minimum” time

Begin taking measurements quickly without fuss

MALDI lends itself to quick analysis through simple sample preparation and acquisition. Once the sample is loaded, users can acquire a spectrum in a few minutes at the click of a button.

With such a smooth and quick setup, it is possible to carry out detailed structural analyses in a very short time span.

“Minimum” sample volume

MSⁿ analysis is possible over a wide mass range, even with microquantity samples

By combining a MALDI ion source with Digital Ion Trap (DIT) technology, it is possible to carry out high-sensitivity MS and MSⁿ analysis even on micro-quantity samples. Not only can the mass of various molecules be checked, but it is also possible to carry out a wide range of analyses such as identifying proteins and investigating the structure of glycans and glycopeptides.

■Identifying protein digests

By carrying out MS and MS/MS measurements on protein digests, it is possible to determine the identify of a protein.

■MALDImini Console

With the dedicated control software for MALDImini-1, you can take measurements just by setting simple analysis parameters. Switch quickly and easily between MS, MS/MS and MS³ modes for seamless analysis. Data can be exported in mzML or mzXML formats.

■Compatibility with Software Solutions

Powerful processing tools can be used to analyze your exported mzML or mzXML data, such as MASCOT for identifying protein digests, SimGlycan for processing MSⁿ data for glycans, and eMSTAT Solution for statistical analysis.

• eMSTAT Solution

■Investigating glycopeptide structure

Through MS, MS/MS and MS³ measurements of synthetic O-linked glycopeptides, the glycan sequence can be found from MS/MS data and the amino acid sequence of the peptide backbone can be found from MS³ data.

MALDImini, eMSTAT Solution and FlexiMass are trademarks of Shimadzu Corporation.
MASCOT is a registered trademark of Matrix Science Ltd.
SimGlycan is a trademark of PREMIER Biosoft International.

The iMScope QT boasts not only fusion with morphology studies but also excellent speed, sensitivity, and spatial resolution, clearing the way to next-generation mass spectrometry imaging.

This instrument is not available in the USA and may not be available in some other countries. Please contact your local Shimadzu representative for availability.

Total System for MS Imaging Analysis

Mass spectrometry imaging is performed in three steps: pretreatment, data acquisition, and data analysis.
At each step, the optimal approach accelerates research, while improving the reliability of the results.

Key Points for MS Imaging

Combined Analysis

Fusion of observations from an optical microscope with MS images
(exclusive to Shimadzu)

MS images can be obtained flexibly and matched to observation images,
either the entire image area or detailed portions of it.

Measurement Results for the Cerebellum with 5 μm Spatial Resolution

• Sample ：Whole mouse brain
• Matrix ：9-AA
• Measurement region ：662×595（393890pix）
• Measurement time: ：around 2.2 hours

The region in the red frame below (cerebellum) was measured with a resolution of 5 μm. High-resolution MS imaging and morphological observations with the optical microscope support cutting-edge research.

Measurement Results for Whole Brain Sections in Negative Mode

• Sample:Whole mouse brain
• Matrix ：9-AA
• Measurement region: ：1126×624（702624pix）
• Measurement time：around 6 hours

The sections of the mouse brain (17 mm × 9.4 mm) were measured at high resolution with a 15 μm pitch (702,624 pixels). The high-resolution analysis of these large brain sections was completed in around 6 hours, enabling testing to proceed efficiently.

Quantification and Distribution

Obtain qualitative and quantitative information from LC-MS as well as position information from mass spectrometry imaging (MSI) with a single instrument.

The combined system, which can perform LC-MS analysis in addition to MSI analysis, provides both distribution information and quantitative analysis.

Use as an MSI System

Sections of mouse tissue administered with chlorpromazine were measured with the iMScope QT. The distribution of unaltered chlorpromazine including differences in abundance could be visualized without the need for labeling.

Use as an LC-MS System

From the consecutive sections, the positions circled in the figure above were excised using laser micro dissection (LMD), and the extracted liquid was measured with the LCMS-9030.
The results below show a quantitative analysis of the concentration of chlorpromazine in the extracted liquid, carried out with LabSolutions Insight. In this way, concentration differences of the pharmaceutical agent in the tissue sections indicated by MSI could be confirmed from the quantitative results determined using LC-MS.

In addition, it is possible to estimate the molecular formula of an unknown compound using the LabSolutions Insight Explore composition estimation function.
In this case, when the peak at m/z = 319.10 determined using MSI was analyzed using the composition estimation function, the molecular formula for the unaltered chlorpromazine substance (C17H19N2SCl) was indicated as the most likely with the highest score.

Results: highest score of 98.99, Diff. 0.15 mDa (0.458 ppm), C17H19N2SCl

High Resolution, Speed and Accuracy

Acquisition of accurate, high-speed, high-resolution MS images, together with efficient data analysis

Combination of the high-accuracy, high-speed LCMS-9030* with high-resolution mass spectrometry imaging

Revolutionary, High Performance Analysis System

After scanning with the built-in optical microscope, the sample plate is moved directly to the ionization position, and the imaging process begins

* The LCMS-9030 is sold separately

Designed for Easy Attachment

The iMScope QT can be easily attached or detached from the LCMS-9030 to switch between mass spectrometry imaging and high-sensitivity LC-MS analysis.

Effortless Performance for Accurate Mass

Excellence in Mass Measurement Accuracy (MMA）

Mass measurement accuracy (MMA) is the key performance attribute underlying all application fields using high-resolution accurate-mass (HRAM) spectrometers. The LCMS-9030 delivers the MMA needed for high-condence identification of unknown compounds at an unprecedented level of stability. This is made possible by new technologies implemented in the Intelligent Temperature Control System and the UF-FlightTube that accurately offset the changes occurring to both internal and external environments. With the LCMS-9030, Shimadzu aims to totally refashion the HRAM user experience, enabling scientists to run more samples at longer calibration intervals with greater confidence and ease.

Stable MMA Against Temperature Fluctuation

Shimadzu’s Intelligent Temperature Control System ensures stable MMA even in laboratory environments susceptible to temperature changes. To demonstrate, standards ranging from 150 to 1700 Da were analyzed continuously after a single calibration. Normal laboratory temperature fluctuation was observed between 25°C and 28°C.

Without additional mass correction, the measured accurate masses of all compounds remained within 1 ppm of the theoretical mass for the 60-hour duration of the experiment. With the LCMS-9030, laboratory productivity can be increased by running long, calibration-free batches with confidence.

Multimodal Imaging System

MALDI-MS molecular imaging data and LA-ICP-MS elemental imaging data can be analyzed using a single software solution. That makes multimodal imaging more accessible.

MALDI-8030

The MALDI-8030 is the latest in a long line of MALDI-TOF products from Shimadzu. Instrument performance specifications is extended from those of the MALDI-8020 to cater for compounds best suited to analysis in negative ion mode. This dual-polarity, benchtop linear MALDI-TOF mass spectrometer delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.
 

Key features:

– Dual mode (positive/negative ion) MALDI-TOF
– 200 Hz solid-state laser, 355 nm
– Load-lock chamber for fast sample introduction
– UV laser-based source cleaning (patented)
– Flexibility
– Small footprint/benchtop design
– Quiet operation (<55 dB)

Sample target solutions

Compatible with the FlexiMass series of microscope slide-format sample targets, these slides provide researchers with options depending on their experimental workflow. The individually barcoded, single-use FlexiMass-DS slides provide a convenient solution for more routine or defined workflows. Ready-to-use, these disposable targets eliminate the need for cleaning and the risk of carryover. Alternatively, the reusable stainless steel FlexiMass-SR sample targets provide a cost-effective, longer-term solution to sample preparation.

TrueClean automated source cleaning

To maintain instrument performance over time, the MALDI-8030 features wide-bore ion optics – a feature used on our existing MALDI-TOF products – which minimize the risk of source contamination over time, providing a robust platform. To maximize uptime, the system is equipped with TrueClean – an automated, rapid (<10 min) UV laser-based source cleaning which can be used to clean the extraction electrode in-situ without breaking instrument vacuum.

Quality as standard

Through the selection of components demonstrating improved longevity and performance, and by reducing the number of component parts, our engineers have created a reliable and robust platform capable of delivering outstanding performance in a small footprint. The MALDI systems are maintained by trained service support engineers who form part of the Shimadzu global distribution and support network. Routine maintenance is simplified thanks to the instrument design, providing our engineers with easy access to commonly serviced parts.

Data management and integrity

 Operating under the control of MALDI Solutions software, the software features a centralized, secure Microsoft^® SQL database which can be used to store everything from sample lists and acquisition Parameter Sets to acquired MALDI data. The system is managed by an Administrator and customizable user profiles provide control over access to the database and operation of the instrument.

The AXIMA Performance is one of the most powerful tools in mass spectrometry, delivering information-rich spectra with greater sensitivity and higher confidence in identification. It is an extremely versatile and powerful TOF-TOF system, integrating workflows for a diverse range of analytical needs.

• From high energy MS/MS of proteomics and other biological and organic samples to uncompromised analysis of high mass intact proteins
• True high energy MS/MS – CID with a laboratory frame collision energy of 20keV
• Optimal precursor ion selection resolution using revolutionary gating technology
• Outstanding sensitivity – uncompromised design, to ensure no MS/MS signal is discarded

Features

Can be used in various research fields

A diverse range of applications are supported, including fully automated proteomics experiments, LC MALDI analyses, functional genomics, quality control and polymer interrogation.

Proteomics suite

• Designed with the flexibility to adapt to users’ workflow: from single sample manual acquisition to fully automated data-dependent peptide mass fingerprinting and MS/MS for protein identification.
• Peptide mass fingerprints are acquired and subjected to an optional integrated Mascot® database search.
• User defined acceptance limits for PMF-based protein identification.
• Data-dependent MS/MS: using the results of the PMF search, MS/MS may be performed on ions that matched to the top ranked protein hit (confirmation MS/MS), in addition to those that were not (investigation MS/MS). Batch searching of these MS/MS spectra is then performed automatically to provide further and higher confidence protein identification.
• Data may be reprocessed and resubmitted for database searching at a later time to provide additional information.

LC MALDI integrated package

• The AXIMA Performance provides total support for LC-MALDI based experiments.
• The software suite allows the fully automated acquisition of LC separated samples deposited onto MALDI targets and the subsequent identification of proteins via MS/MS of the peptides detected.
• Automatically provides a provisional intensity map of all sample spots across the target to assess the distribution of peptides and identify the position of the apex of the chromatographic peaks. These are utilized to generate a candidate list and MS/MS data acquired for all discrete peptide ions.
• Exclusion lists are used to remove known contaminants or high abundance peptides.
• All data is subjected to an integrated Mascot® search.
• Low sample consumption allows multiple spectra to be acquired from the same spot increasing the amount of MS/MS data obtained.

Biomarker Recognition/Tissue Imaging

• Seamless export of sample location to the Axima MALDI mass spectrometer
• Automated acquisition of MS data – profiling or imaging
• Visualization of the spatial distribution of components of interest via intensity mapping software
• Easy export of data to alternative processing packages, including BioMAP

Other features

Essential features providing confident results

• High resolution MS data in reflectron mode for more accurate and confident peptide mass fingerprinting (PMF) and complex mixture analysis.
• Uncompromised linear mass range and sensitivity.
• Near-axis laser irradiation for enhanced ion transmission and sensitivity in all modes of operation.
• Advanced calibration algorithms with easy to use software providing more accurate data.
• Intuitive software incorporating data dependent workflows for achieving the maximum result with the minimum user input, making it ideal for novice and expert users alike.
• Flexibility – this is not just another proteomics workhorse. Polymers, oligonucleotides, SNPs, metabolites, carbohydrates and small molecules amongst others may all be analysed and processed.

Key Performance Features

• Near-axis laser irradiation with a 50Hz variable repetition rate N2 laser
• Uncompromised linear mode performance for high mass analysis
• Patented improved curved field reflectron
• Mass range 1-500kDa in linear mode; 1-80kDa in reflectron mode
• Mass resolution 5000 FWHM (ACTH 18-39) in linear mode; 20000 FWHM (ACTH 7-38) in reflectron mode
• Sensitivity 250 amol (Glu-fibrinopeptide) in reflectron mode
• Mass accuracy <5ppm in reflectron mode
• Precursor ion resolution >400 FWHM
• High energy MS/MS using helium collision gas
• Flexible target formats – ranging from 48 well microscope slide format targets to 384 well microtitre plate targets

Additional Key Features and Benefits

• Proteomics experiments
• LC MALDI
• Tissue imaging/biomarker discovery
• Polymer analysis
• Oligonucleotide/primer analysis
• Full integration with robotic sample preparation devices such as the Accuspot and ChIP for a variety of applications