Hybrid Technology for Versatility and Superior Performance

Broad pH tolerance (pH 1 to 12*) for use with a wide range of method conditions Eight stationary phases and Three column hardware types for extensive sample coverage Scalability from analytical UHPLC to preparative purification applications

Achieve excellent stability and performance over a wide range of LC conditions with Shim-pack Scepter- the next generation organic silica hydrid-based LC columns. Featuring different ligand functional groups, Shim-pack Scepter columns are effective for method development/scouting, and are suitable for a wide variety of applications and sample types. The three particle sizes (1.9 µm, 3 µm, 5 µm) and wide range of column dimensions make Shim-pack Scepter LC columns fully scalable between UHPLC, HPLC, and preparative LC for seamless method transfer between different laboratory instrumentation.

Even for LC columns that claim to be designed for basic compounds, adequate resolution often can not be obtained due to problems such as leading of highly polar basic compounds, peak shape deterioration of acidic compounds, or long equilibration time required for low ionic strength acidic mobile phase. All of these issues have been solved with Shim-pack Arata that was specically designed to give unmatched peak shape for basic compounds.

Designed to maximize performance of LC systems, Shimadzu’s Shim-pack Velox columns with core shell technology enable you to achieve increased separations and faster analysis times on any LC platform. Whether developing a high efficiency LC separation method, transferring an existing method for increased throughput while maintaining resolution, or are trying to improve the resolution of a complex separation, Shim-pack Velox columns will satisfy your needs. Column ruggedness is  critical to any LC analysis and Shim-pack Velox core-shell columns deliver excellent column lifetime for even the most challenging sample matrices.

Fully Porous Silica Particle Based Column Series

Shim-pack GIST Series ~ High Inert & Highly Stable Fully Porous Silica Column Series ~

• Excellent peak shape and stability achieved by using uniquely modified high purity fully porous silica particles
• Excellent lot to lot reproducibility

Shim-pack GISS Series ~ High Speed Analysis with High Inertness and High Stability ~

• Optimization of surface area of the inert fully porous silica using wider pore sizes provides rapid separation with excellent peak shapes

Shim-pack GIS Series ~ High Surface Area Fully Porous Silica ~

• Shim-pack GIS C18 is a fully porous high surface area column offering high retention and suitable fore preparative purification application.

Solution for Analysis of Peptides, Oligonucleotides and Biopharmaceuticals

The accurate analysis of biopharmaceuticals compounds is required for developing higher quality biopharmaceuticals. Shim-pack Bio
Diol and IEX columns will improve the accuracy of the characterization of peptides, oligonucleotide and biopharmaceuticals.

Shim-pack VP-ODS columns are standard columns that use a homogeneous high-purity silica gel as the substrate. They achieve analysis with a high number of theoretical plates without raising the pressure.
They optimize the surface modification ratio and provide favorable peak shapes and separation for compounds with a wide range of physical properties.

Shim-pack VP series ensures high column-to-column performance reproducibility, which is ideal for method development and validation. Silica-bases, surface treatment and packing procedures are subjected to a strict array of quality criteria tests and controlled respectively. Each column is delivered together with Certificate of Compliance and Column Performance Report.

Shim-pack XR-ODS II / III

While the Shim-pack XR-ODSII and XR-ODS III use the same 2.2 μm packing particle size as the Shim-pack XR Series columns, they have higher 60 and 100MPa pressure tolerance. This allows them to achieve high-resolution fast analysis in a long column using a water/methanol mobile phase. This column significantly extends the range of applications of high-resolution fast analysis to include analysis near room temperature.

Shim-pack XR Series

Shim-pack XR Series columns use a 2.2 μm packing particle size and offer a skillful balance between resolution efficiency and pressure. An XR Series column provides resolution equivalent to a general-purpose column with 5 μm packing particle size (Shim-pack VP-ODS), but significantly reduces the analysis time. The pressure on the column under many analysis conditions does not exceed 35 MPa. Consequently, ultrafast analysis can be comfortably performed on an existing instrument.

Shim-pack MAqC-ODS I reversed-phase columns are packed with a silica gel containing metal and bonded octadecylsilyl group. In addition to the hydrophobic characteristics of the ODS, the metal content also provides cation-exchange effects. This increases the retention of basic compounds. Therefore, this allows use with only a buffer solution as the mobile phase for analyses that previously required using an ion pair reagent and enables using gradient elution. These characteristics are especially beneficial for analyzing
water soluble vitamins and pharmaceuticals that contain a large amount of basic compounds.