| |
LC-VP Series Validation and Productivity
The LC-VP series is a modular type HPLC system designed for validation and productivity. Each unit is equipped with a special VP key that enables quick execution of various checks for the unit, including periodic and routine checks for compliance with GLP/GMP regulations. Product information, maintenance information, validation support and calibration support are controlled by the VP key. Users can utilize the key to display and record instrumental information and output validation results to the Chromatopac (C-R7A) or LC workstation (CLASS-VP) through the system controller, making validation and calibration work more automated and efficient.
The LC-VP series units provide a high level of performance. The sol-vent delivery unit LC-10ADve, which makes full use of new micro plunger technology, enables highly accurate pulseless solvent delivery that fully utilizes the capacity of detectors sensitive to pulsation.
The autoinjector SIL-10ADvp, which employs a plunger type lightweight pump with 6nL/step resolution, has superb reproducibility even for micro volume injections. The recently marketed high-throughput autoinjector SIL-HT has the industry's shortest sample injection time, just 15 seconds, and enables the loading of up to four microplates, to assure an optimum HPLC environment as the front end for LC-MS or LC-MSMS systems. The LC-VP series also provides a choice of high-sensitivity detectors, including the UV-VIS detector SPD-10Avz, the spectrofluorometric detector RF-10AxL and the refractive index detector RID-10A. The photodiode array detector SPD-M10Ave has both high sensitivity and high resolution without changing the slit width.
The LC-VP series can be used for various applications as a truly reliable HPLC system with excel-lent expandability. |
The LC-2010 is a next-generation HPLC based on the concept of high-throughput analysis and automated validation.
Seven analyses all done in 15minutes thanks to high-speed injection and an ultra fast column.
This enables major improvements in analysis throughput in the field of drug discovery.
|
LC-2010 High-Throughput
The LC-2010, designed with productivity, reliability and efficiency as the core concept, is a next-generation intelligent HPLC that integrates many advanced technologies. It stands out in the HPLC field for many reasons including high throughput, automation, validation and ease of use.
- High Throughput
World's fastest sample injection at 15 sec/10mL.
The LC-2010 autosampler can handle up to 850 vials of 1mL volume. When the 884-well microtiter plates are incorporated into the system, the LC-2010 can process 1586 samples at once.
- Automation
All analysis procedures, from sys-tem startup to shutdown, can be completely automated. This automation includes a baseline stability check as well as opening and closing of the drain valve.
- Validation
System validation and verification of operation have both been automated by the auto validation function.
- Ease of operation
Wizard functions simplify operations and allow even a beginning user to easily perform any analysis. Micro plunger technology and dynamic inlet valve further improve reproducibility, while the cell temperature control function and new optical processing technology achieve high detection linearity and stability. The LC-2010 is the optimum HPLC for standardized analyses.
 |
The Co-Sense systems offer significant advantages for investigation of in vivo and in vitro metabolism and analysis of side reactions in chemical analysis. |
Application Systems for Specific Needs
Most HPLC models are multipurpose analyzers with a broad range of applications. There is also great demand, however, for specialist HPLC models customized for specific uses. Early on, Shimadzu began developing such application systems and currently produces a wide range:
- Amino acid analysis system
- Organic acid analysis system
- Sugar analysis system
- Ion chromatograph
- Transition metal analysis system
- Cyan analysis system
- Carbamate pesticides analysis system
- Bromic acid analysis system
- GPC analysis system
- Auto sample pretreatment system for NMR/MS
- Cleaning validation support system
- Bio-sample analysis system
- GPC cleanup system
- Dioxins cleanup system
While application systems were once developed simply to meet requirements for analyzing specific compounds, they are now regarded as total systems that enhance the efficiency of analyses in specificfields. For example, the automatic sample pretreatment system for NMR/MS, cleaning validation support system and bio-sample analysis system were jointly developed with users to make pharmaceutical analysis more efficient, and have enabled swifter development of pharmaceuticals. The following are brief introductions to three major application systems.
Automatic Sample Pretreatment System for NMR/MS (Co-Sense for LC-NMR/MS)
Co-Sense for LC-NMR/MS, a sample pretreatment system for LC/NMR (liquid chromatography nuclear magnetic resonance) or LC/MS (liquid chromatography mass spectrometry) structural analysis of compounds, was developed to reduce measurement time and running cost. Sample processing separation and concentration of target substances from the sample and solvent substitute (substitution with deuterium sol-vent for NMR) is fully automated, which eliminates complex and expensive manual procedures, as well as increases the reliability of the data. Additionally, the Co-Sense for LC-NMR/MS allows users to set optimum LC parameters independent of the NMR/MS measurement conditions.
Co-Sense for LC-NMR/MS, originally designed specifically for structural analysis of impurities in pharmaceuticals, has also proven to be a powerful tool for NMR/MS measurement in life science and chemical industry fields, including research into metabolic substances in organisms and analysis of side reactions in chemical synthesis.
Cleaning Validation Support System (Co-Sense for CV)
Co-Sense for CV, being developed to increase efficiency in cleaning validation of pharmaceutical manufacturing equipment, automatically performs consecutive operations from sample pretreatment to residue and threshold calculations to pass/fail judgments, with specially developed software and a unique system configuration based on column switching technology.
The hardware for the Co-Sense for CV consists of a concentration unit to concentrate samples and an analysis unit that detects target components. These are connected with a switching valve. In the concentration unit, the desired solvent is used to dilute the sample for concentration of target components in a concentration column. In the analysis unit, tar-get components from the concentration column are inducted into the analysis column, and then separately detected and quantified.
The software calculates the amount of pharmaceutical sub-stances remaining in the equipment after the production process, using data acquired from the LC workstation CLASS-VP version 6.1, and then compares it with the threshold set by the user to evaluate pass/fail of the equipment,
Bio-sample Analysis System (Co-Sense for BA)
Co-Sense for BA, an analysis sys-tem for drugs in bio-samples, smoothly performs all operations from sample pretreatment to analysis, taking advantage of a unique system configuration based on column switching technology and the pretreatment column.
Co-Sense for BA enables direct injection of bio-samples such as plasma, as well as removal of sub-stances that hinder MS measurement, including proteins and ionic substances.
LC/MS Liquid Chromatograph-Mass Spectrometer
The LC/MS detects the molecular weights of a compound in just a few minutes, demonstrating its superiority for research work in the development of new drugs and analyse of the environment.
Shimad2u LCMS-2010 is a high-sensitivity LC/MS. |
|
|
Development of Shimadzu's HPLC Business 
Bara Scientific 
